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Furthermore, NOX4 has been implicated in other major human pathologies, including metabolic diseases, neurodegeneration and osteoporosis

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Treatment Options for Melasma and Sun Spots Topical Treatments For both conditions, first-line treatments often include: Hydroquinone-based creams (prescription-strength) Retinoids Vitamin C serums Kojic acid Azelaic acid Tranexamic acid While these treatments can be effective, especially for mild cases, they typically require consistent long-term use, and results can be limited

10.4049/jimmunol.1302338 [DOI] [PubMed] [Google Scholar] Benkhoucha M., Santiago-Raber M